| Title |
Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes
|
|---|---|
| Published in |
Science, November 2014
|
| DOI | 10.1126/science.1258522 |
| Pubmed ID | |
| Authors |
Daniel E Neafsey, Robert M Waterhouse, Mohammad R Abai, Sergey S Aganezov, Max A Alekseyev, James E Allen, James Amon, Bruno Arcà, Peter Arensburger, Gleb Artemov, Lauren A Assour, Hamidreza Basseri, Aaron Berlin, Bruce W Birren, Stephanie A Blandin, Andrew I Brockman, Thomas R Burkot, Austin Burt, Clara S Chan, Cedric Chauve, Joanna C Chiu, Mikkel Christensen, Carlo Costantini, Victoria L M Davidson, Elena Deligianni, Tania Dottorini, Vicky Dritsou, Stacey B Gabriel, Wamdaogo M Guelbeogo, Andrew B Hall, Mira V Han, Thaung Hlaing, Daniel S T Hughes, Adam M Jenkins, Xiaofang Jiang, Irwin Jungreis, Evdoxia G Kakani, Maryam Kamali, Petri Kemppainen, Ryan C Kennedy, Ioannis K Kirmitzoglou, Lizette L Koekemoer, Njoroge Laban, Nicholas Langridge, Mara K N Lawniczak, Manolis Lirakis, Neil F Lobo, Ernesto Lowy, Robert M MacCallum, Chunhong Mao, Gareth Maslen, Charles Mbogo, Jenny McCarthy, Kristin Michel, Sara N Mitchell, Wendy Moore, Katherine A Murphy, Anastasia N Naumenko, Tony Nolan, Eva M Novoa, Samantha O'Loughlin, Chioma Oringanje, Mohammad A Oshaghi, Nazzy Pakpour, Philippos A Papathanos, Ashley N Peery, Michael Povelones, Anil Prakash, David P Price, Ashok Rajaraman, Lisa J Reimer, David C Rinker, Antonis Rokas, Tanya L Russell, N'Fale Sagnon, Maria V Sharakhova, Terrance Shea, Felipe A Simão, Frederic Simard, Michel A Slotman, Pradya Somboon, Vladimir Stegniy, Claudio J Struchiner, Gregg W C Thomas, Marta Tojo, Pantelis Topalis, José M C Tubio, Maria F Unger, John Vontas, Catherine Walton, Craig S Wilding, Judith H Willis, Yi-Chieh Wu, Guiyun Yan, Evgeny M Zdobnov, Xiaofan Zhou, Flaminia Catteruccia, George K Christophides, Frank H Collins, Robert S Cornman, Andrea Crisanti, Martin J Donnelly, Scott J Emrich, Michael C Fontaine, William Gelbart, Matthew W Hahn, Immo A Hansen, Paul I Howell, Fotis C Kafatos, Manolis Kellis, Daniel Lawson, Christos Louis, Shirley Luckhart, Marc A T Muskavitch, José M Ribeiro, Michael A Riehle, Igor V Sharakhov, Zhijian Tu, Laurence J Zwiebel, Nora J Besansky |
| Abstract |
Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts. |
X Demographics
The data shown below were collected from the profiles of 148 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 28 | 19% |
| United Kingdom | 13 | 9% |
| Spain | 6 | 4% |
| Australia | 3 | 2% |
| Canada | 3 | 2% |
| India | 3 | 2% |
| Argentina | 2 | 1% |
| Grenada | 2 | 1% |
| Germany | 2 | 1% |
| Other | 21 | 14% |
| Unknown | 65 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 90 | 61% |
| Scientists | 51 | 34% |
| Science communicators (journalists, bloggers, editors) | 4 | 3% |
| Practitioners (doctors, other healthcare professionals) | 3 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 972 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 2% |
| Brazil | 7 | <1% |
| Colombia | 4 | <1% |
| United Kingdom | 4 | <1% |
| Germany | 3 | <1% |
| Netherlands | 2 | <1% |
| Mexico | 2 | <1% |
| Switzerland | 2 | <1% |
| France | 1 | <1% |
| Other | 13 | 1% |
| Unknown | 915 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 214 | 22% |
| Researcher | 204 | 21% |
| Student > Master | 119 | 12% |
| Student > Bachelor | 80 | 8% |
| Other | 45 | 5% |
| Other | 173 | 18% |
| Unknown | 137 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 447 | 46% |
| Biochemistry, Genetics and Molecular Biology | 197 | 20% |
| Medicine and Dentistry | 25 | 3% |
| Environmental Science | 24 | 2% |
| Immunology and Microbiology | 23 | 2% |
| Other | 93 | 10% |
| Unknown | 163 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 306. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2024.
All research outputs
#114,157
of 25,715,849 outputs
Outputs from Science
#3,677
of 83,253 outputs
Outputs of similar age
#1,110
of 371,361 outputs
Outputs of similar age from Science
#39
of 824 outputs
Altmetric has tracked 25,715,849 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,253 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 95% of its peers.
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