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A highly virulent variant of HIV-1 circulating in the Netherlands

Overview of attention for article published in Science, February 2022
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Title
A highly virulent variant of HIV-1 circulating in the Netherlands
Published in
Science, February 2022
DOI 10.1126/science.abk1688
Pubmed ID
Authors

Chris Wymant, Daniela Bezemer, François Blanquart, Luca Ferretti, Astrid Gall, Matthew Hall, Tanya Golubchik, Margreet Bakker, Swee Hoe Ong, Lele Zhao, David Bonsall, Mariateresa de Cesare, George MacIntyre-Cockett, Lucie Abeler-Dörner, Jan Albert, Norbert Bannert, Jacques Fellay, M. Kate Grabowski, Barbara Gunsenheimer-Bartmeyer, Huldrych F. Günthard, Pia Kivelä, Roger D. Kouyos, Oliver Laeyendecker, Laurence Meyer, Kholoud Porter, Matti Ristola, Ard van Sighem, Ben Berkhout, Paul Kellam, Marion Cornelissen, Peter Reiss, Christophe Fraser, V. Aubert, M. Battegay, E. Bernasconi, J. Böni, D. L. Braun, H. C. Bucher, C. Burton-Jeangros, A. Calmy, M. Cavassini, G. Dollenmaier, M. Egger, L. Elzi, J. Fehr, J. Fellay, H. Furrer, C. A. Fux, M. Gorgievski, H. Günthard, D. Haerry, B. Hasse, H. H. Hirsch, M. Hoffmann, I. Hösli, C. Kahlert, L. Kaiser, O. Keiser, T. Klimkait, R. Kouyos, H. Kovari, B. Ledergerber, G. Martinetti, B. Martinez de Tejada, C. Marzolini, K. Metzner, N. Müller, D. Nadal, D. Nicca, G. Pantaleo, A. Rauch, S. Regenass, C. Rudin, F. Schöni-Affolter, P. Schmid, R. Speck, M. Stöckle, P. Tarr, A. Trkola, P. Vernazza, R. Weber, S. Yerly, M. van der Valk, S. E. Geerlings, A. Goorhuis, J. W. Hovius, B. Lempkes, F. J. B. Nellen, T. van der Poll, J. M. Prins, P. Reiss, M. van Vugt, W. J. Wiersinga, F. W. M. N. Wit, M. van Duinen, J. van Eden, A. Hazenberg, A. M. H. van Hes, F. J. J. Pijnappel, S. Y. Smalhout, A. M. Weijsenfeld, S. Jurriaans, N. K. T. Back, H. L. Zaaijer, B. Berkhout, M. T. E. Cornelissen, C. J. Schinkel, K. C. Wolthers, E. J. G. Peters, M. A. van Agtmael, R. S. Autar, M. Bomers, K. C. E. Sigaloff, M. Heitmuller, L. M. Laan, C. W. Ang, R. van Houdt, M. Jonges, T. W. Kuijpers, D. Pajkrt, H. J. Scherpbier, C. de Boer, A. van der Plas, M. van den Berge, A. Stegeman, S. Baas, L. Hage de Looff, A. Buiting, A. Reuwer, J. Veenemans, B. Wintermans, M. J. H. Pronk, H. S. M. Ammerlaan, D. N. J. van den Bersselaar, E. S. de Munnik, B. Deiman, A. R. Jansz, V. Scharnhorst, J. Tjhie, M. C. A. Wegdam, A. van Eeden, J. Nellen, W. Brokking, L. J. M. Elsenburg, H. Nobel, M. E. E. van Kasteren, M. A. H. Berrevoets, A. E. Brouwer, A. Adams, R. van Erve, B. A. F. M. de Kruijf-van de Wiel, S. Keelan-Phaf, B. van de Ven, B. van der Ven, A. G. M. Buiting, J. L. Murck, T. E. M. S. de Vries-Sluijs, H. I. Bax, E. C. M. van Gorp, N. C. de Jong-Peltenburg, M. de Mendonç̧a Melo, E. van Nood, J. L. Nouwen, B. J. A. Rijnders, C. Rokx, C. A. M. Schurink, L. Slobbe, A. Verbon, N. Bassant, J. E. A. van Beek, M. Vriesde, L. M. van Zonneveld, J. de Groot, C. A. B. Boucher, M. P. G. Koopmans, J. J. A. van Kampen, P. L. A. Fraaij, A. M. C. van Rossum, C. L. Vermont, L. C. van der Knaap, E. Visser, J. Branger, R. A. Douma, A. S. Cents-Bosma, C. J. H. M. Duijf-van de Ven, E. F. Schippers, C. van Nieuwkoop, J. M. van Ijperen, J. Geilings, G. van der Hut, N. D. van Burgel, E. M. S. Leyten, L. B. S. Gelinck, F. Mollema, S. Davids-Veldhuis, C. Tearno, G. S. Wildenbeest, E. Heikens, P. H. P. Groeneveld, J. W. Bouwhuis, A. J. J. Lammers, S. Kraan, A. G. W. van Hulzen, M. S. M. Kruiper, G. L. van der Bliek, P. C. J. Bor, S. B. Debast, G. H. J. Wagenvoort, F. P. Kroon, M. G. J. de Boer, H. Jolink, M. M. C. Lambregts, A. H. E. Roukens, H. Scheper, W. Dorama, N. van Holten, E. C. J. Claas, E. Wessels, J. G. den Hollander, R. El Moussaoui, K. Pogany, C. J. Brouwer, J. V. Smit, D. Struik-Kalkman, T. van Niekerk, O. Pontesilli, S. H. Lowe, A. M. L. Oude Lashof, D. Posthouwer, M. E. van Wolfswinkel, R. P. Ackens, K. Burgers, J. Schippers, B. Weijenberg-Maes, I. H. M. van Loo, T. R. A. Havenith, M. G. A. van Vonderen, L. M. Kampschreur, S. Faber, R. Steeman-Bouma, A. Al Moujahid, G. J. Kootstra, C. E. Delsing, M. van der Burg-van de Plas, L. Scheiberlich, W. Kortmann, G. van Twillert, R. Renckens, D. Ruiter-Pronk, F. A. van Truijen-Oud, J. W. T. Cohen Stuart, ER. Jansen, M. Hoogewerf, W. Rozemeijer, W. A. van der Reijden, J. C. Sinnige, K. 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Schölvinck, Y. Stienstra, A. R. Verhage, M. Wouthuyzen-Bakker, A. Boonstra, H. de Groot-de Jonge, P. A. van der Meulen, D. A. de Weerd, H. G. M. Niesters, C. C. van Leer-Buter, M. Knoester, A. I. M. Hoepelman, J. E. Arends, R. E. Barth, A. H. W. Bruns, P. M. Ellerbroek, T. Mudrikova, J. J. Oosterheert, E. M. Schadd, B. J. van Welzen, K. Aarsman, B. M. G. Griffioen-van Santen, I. de Kroon, M. van Berkel, C. S. A. M. van Rooijen, R. Schuurman, F. Verduyn-Lunel, A. M. J. Wensing, L. J. Bont, S. P. M. Geelen, Y. G. T. Loeffen, T. F. W. Wolfs, N. Nauta, E. O. W. Rooijakkers, H. Holtsema, R. Voigt, D. van de Wetering, A. Alberto, I. van der Meer, A. Rosingh, T. Halaby, S. Zaheri, A. C. Boyd, D. O. Bezemer, A. I. van Sighem, C. Smit, M. Hillebregt, A. de Jong, T. Woudstra, D. Bergsma, R. Meijering, L. van de Sande, T. Rutkens, S. van der Vliet, L. de Groot, M. van den Akker, Y. Bakker, A. El Berkaoui, M. Bezemer, N. Brétin, E. Djoechro, M. Groters, E. Kruijne, K. J. Lelivelt, C. Lodewijk, E. Lucas, L. Munjishvili, F. Paling, B. Peeck, C. Ree, R. Regtop, Y. Ruijs, M. Schoorl, P. Schnörr, A. Scheigrond, E. Tuijn, L. Veenenberg, K. M. Visser, E. C. Witte, Y. 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Brewer, Christoph Mayr, Wolfgang Schmidt, Andrea Speidel, Frank Strohbach, Keikawus Arastéh, Christiane Cordes, Manfred Stündel, Jörg Claus, Axel Baumgarten, Andreas Carganico, Patrick Ingiliz, Stephan Dupke, Matthias Freiwald, Michael Rausch, Arend Moll, Dorothea Schleehauf, Bettina Hintsche, Gerd Klausen, Heiko Jessen, Arne Jessen, Siegfried Köppe, Peter Kreckel, Dietmar Schranz, Klaus Fischer, Hubert Schulbin, Miriam Speer, Tobias Glaunsinger, Thomas Wicke, Bernhard Bieniek, Heribert Hillenbrand, Frank Schlote, Elke Lauenroth-Mai, Christoph Schuler, Dirk Schürmann, Hans Wesselmann, Norbert Brockmeyer, Peter Gehring, Dirk Schmalöer, Martin Hower, Petra Spornraft-Ragaller, Dieter Häussinger, Stefan Reuter, Stefan Esser, Rudolf Markus, Burkhard Kreft, Dirk Berzow, Andreas Christl, Andreas Meyer, Andreas Plettenberg, Albrecht Stoehr, Katrin Graefe, Thore Lorenzen, Axel Adam, Knut Schewe, Lutwin Weitner, Stefan Fenske, Stefan Hansen, Hans-Jürgen Stellbrink, Dorothea Wiemer, Sandra Hertling, Reinhold Schmidt, Peter Arbter, Bernd Claus, Peter Galle, Hans Jäger, Eva Jä̈gel-Guedes, Nils Postel, Monika Fröschl, Christoph Spinner, Johannes Bogner, Bernd Salzberger, Jürgen Schölmerich, Franz Audebert, Ties Marquardt, Andreas Schaffert, Eiko Schnaitmann, Andreas Trein, Bernhard Frietsch, Marcus Müller, Albrecht Ulmer, Barbara Detering-Hübner, Peter Kern, Franz Schubert, Günther Dehn, Maria Schreiber, Cengiz Güler, Barbara Gunsenheimer-Bartmeyer, Daniel Schmidt, Karolin Meixenberger, Norbert Bannert

Abstract

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2,048 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 167 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 167 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 16%
Student > Bachelor 17 10%
Student > Ph. D. Student 15 9%
Other 8 5%
Student > Postgraduate 8 5%
Other 32 19%
Unknown 60 36%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 23 14%
Immunology and Microbiology 20 12%
Medicine and Dentistry 17 10%
Agricultural and Biological Sciences 13 8%
Unspecified 6 4%
Other 23 14%
Unknown 65 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3708. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2024.
All research outputs
#1,430
of 25,595,500 outputs
Outputs from Science
#83
of 83,131 outputs
Outputs of similar age
#90
of 519,786 outputs
Outputs of similar age from Science
#4
of 429 outputs
Altmetric has tracked 25,595,500 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,131 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 519,786 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 429 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.