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Systematic humanization of yeast genes reveals conserved functions and genetic modularity

Overview of attention for article published in Science, May 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Citations

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355 Dimensions

Readers on

mendeley
720 Mendeley
citeulike
8 CiteULike
Title
Systematic humanization of yeast genes reveals conserved functions and genetic modularity
Published in
Science, May 2015
DOI 10.1126/science.aaa0769
Pubmed ID
Authors

Aashiq H Kachroo, Jon M Laurent, Christopher M Yellman, Austin G Meyer, Claus O Wilke, Edward M Marcotte

Abstract

To determine whether genes retain ancestral functions over a billion years of evolution and to identify principles of deep evolutionary divergence, we replaced 414 essential yeast genes with their human orthologs, assaying for complementation of lethal growth defects upon loss of the yeast genes. Nearly half (47%) of the yeast genes could be successfully humanized. Sequence similarity and expression only partly predicted replaceability. Instead, replaceability depended strongly on gene modules: Genes in the same process tended to be similarly replaceable (e.g., sterol biosynthesis) or not (e.g., DNA replication initiation). Simulations confirmed that selection for specific function can maintain replaceability despite extensive sequence divergence. Critical ancestral functions of many essential genes are thus retained in a pathway-specific manner, resilient to drift in sequences, splicing, and protein interfaces.

X Demographics

X Demographics

The data shown below were collected from the profiles of 236 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 720 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 13 2%
United Kingdom 5 <1%
Canada 3 <1%
Brazil 2 <1%
Italy 2 <1%
Russia 2 <1%
Spain 2 <1%
Korea, Republic of 2 <1%
South Africa 1 <1%
Other 8 1%
Unknown 680 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 188 26%
Researcher 129 18%
Student > Bachelor 86 12%
Student > Master 66 9%
Student > Doctoral Student 41 6%
Other 108 15%
Unknown 102 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 266 37%
Biochemistry, Genetics and Molecular Biology 244 34%
Chemistry 15 2%
Medicine and Dentistry 14 2%
Engineering 11 2%
Other 52 7%
Unknown 118 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 373. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2024.
All research outputs
#85,106
of 25,584,565 outputs
Outputs from Science
#2,924
of 83,124 outputs
Outputs of similar age
#822
of 282,003 outputs
Outputs of similar age from Science
#40
of 1,328 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,124 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,003 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,328 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.