Title |
NLR immune receptor–nanobody fusions confer plant disease resistance
|
---|---|
Published in |
Science, March 2023
|
DOI | 10.1126/science.abn4116 |
Pubmed ID | |
Authors |
Jiorgos Kourelis, Clemence Marchal, Andres Posbeyikian, Adeline Harant, Sophien Kamoun |
Abstract |
Plant pathogens cause recurrent epidemics, threatening crop yield and global food security. Efforts to retool the plant immune system have been limited to modifying natural components and can be nullified by the emergence of new pathogen strains. Made-to-order synthetic plant immune receptors provide an opportunity to tailor resistance to pathogen genotypes present in the field. In this work, we show that plant nucleotide-binding, leucine-rich repeat immune receptors (NLRs) can be used as scaffolds for nanobody (single-domain antibody fragment) fusions that bind fluorescent proteins (FPs). These fusions trigger immune responses in the presence of the corresponding FP and confer resistance against plant viruses expressing FPs. Because nanobodies can be raised against most molecules, immune receptor-nanobody fusions have the potential to generate resistance against plant pathogens and pests delivering effectors inside host cells. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 19 | 5% |
United Kingdom | 14 | 3% |
Germany | 8 | 2% |
India | 6 | 1% |
Pakistan | 3 | <1% |
France | 3 | <1% |
Spain | 3 | <1% |
Switzerland | 2 | <1% |
Canada | 2 | <1% |
Other | 15 | 4% |
Unknown | 336 | 82% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 202 | 49% |
Members of the public | 197 | 48% |
Science communicators (journalists, bloggers, editors) | 9 | 2% |
Practitioners (doctors, other healthcare professionals) | 3 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 183 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 30 | 16% |
Student > Ph. D. Student | 23 | 13% |
Student > Master | 15 | 8% |
Student > Bachelor | 11 | 6% |
Student > Doctoral Student | 8 | 4% |
Other | 27 | 15% |
Unknown | 69 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 62 | 34% |
Biochemistry, Genetics and Molecular Biology | 33 | 18% |
Arts and Humanities | 2 | 1% |
Unspecified | 2 | 1% |
Immunology and Microbiology | 2 | 1% |
Other | 7 | 4% |
Unknown | 75 | 41% |