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| Title |
NLR immune receptor–nanobody fusions confer plant disease resistance
|
|---|---|
| Published in |
Science, March 2023
|
| DOI | 10.1126/science.abn4116 |
| Pubmed ID | |
| Authors |
Jiorgos Kourelis, Clemence Marchal, Andres Posbeyikian, Adeline Harant, Sophien Kamoun |
| Abstract |
Plant pathogens cause recurrent epidemics, threatening crop yield and global food security. Efforts to retool the plant immune system have been limited to modifying natural components and can be nullified by the emergence of new pathogen strains. Made-to-order synthetic plant immune receptors provide an opportunity to tailor resistance to pathogen genotypes present in the field. In this work, we show that plant nucleotide-binding, leucine-rich repeat immune receptors (NLRs) can be used as scaffolds for nanobody (single-domain antibody fragment) fusions that bind fluorescent proteins (FPs). These fusions trigger immune responses in the presence of the corresponding FP and confer resistance against plant viruses expressing FPs. Because nanobodies can be raised against most molecules, immune receptor-nanobody fusions have the potential to generate resistance against plant pathogens and pests delivering effectors inside host cells. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 5% |
| United Kingdom | 14 | 3% |
| Germany | 8 | 2% |
| India | 6 | 1% |
| Pakistan | 3 | <1% |
| France | 3 | <1% |
| Spain | 3 | <1% |
| Switzerland | 2 | <1% |
| Canada | 2 | <1% |
| Other | 15 | 4% |
| Unknown | 336 | 82% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 202 | 49% |
| Members of the public | 197 | 48% |
| Science communicators (journalists, bloggers, editors) | 9 | 2% |
| Practitioners (doctors, other healthcare professionals) | 3 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 183 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 16% |
| Student > Ph. D. Student | 23 | 13% |
| Student > Master | 15 | 8% |
| Student > Bachelor | 11 | 6% |
| Student > Doctoral Student | 8 | 4% |
| Other | 27 | 15% |
| Unknown | 69 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 62 | 34% |
| Biochemistry, Genetics and Molecular Biology | 33 | 18% |
| Arts and Humanities | 2 | 1% |
| Unspecified | 2 | 1% |
| Immunology and Microbiology | 2 | 1% |
| Other | 7 | 4% |
| Unknown | 75 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 323. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2024.
All research outputs
#110,608
of 26,480,347 outputs
Outputs from Science
#3,545
of 84,062 outputs
Outputs of similar age
#2,946
of 431,356 outputs
Outputs of similar age from Science
#72
of 399 outputs
Altmetric has tracked 26,480,347 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 84,062 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 66.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 431,356 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 399 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.