RT @PasteurVirology: Check out the recent findings @ScienceMagazine from an international collaboration on how to improve the search for "…
RT @PasteurVirology: Check out the recent findings @ScienceMagazine from an international collaboration on how to improve the search for "…
RT @PasteurVirology: Check out the recent findings @ScienceMagazine from an international collaboration on how to improve the search for "…
RT @PasteurVirology: Check out the recent findings @ScienceMagazine from an international collaboration on how to improve the search for "…
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
Will be taking a very careful look through this tomorrow but this would appear critically important for drug repurposing screens for antivirals👇
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
RT @silex_transl: #HCQ 等23種の #転用COVID19 薬の「抗ウイルス効果」が、#CADs によるリソソームリン脂質擾乱効果に還元されることを示す。ビトロ実験で顕著、resources will be saved by counter-screenin…
#HCQ 等23種の #転用COVID19 薬の「抗ウイルス効果」が、#CADs によるリソソームリン脂質擾乱効果に還元されることを示す。ビトロ実験で顕著、resources will be saved by counter-screening for phospholipidosis in simple assays、臨床試験を止めよ、と:UCSF。 https://t.co/Mpn7pkEFe8
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
'Still, the in vitro activities of the phospholipidosis-inducing drugs did not readily translate in vivo, and drugs whose antiviral activity arises due to phospholipidosis seem non-viable for clinical progression.' https://t.co/4asxzVYPov https://t.co/Con
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
Part of what I love about this paper is: the authors are poking holes in their own prior drug-repurposing work (https://t.co/imz690I1q4). Find weaknesses in your prior work, suggest ways to improve on it going forward in a crucial area. This is how science
Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for in vitro drug repurposing vs SARS-CoV-2: compounds that block membrane trafficking account for an alarming % of early hits but a
'The new paper makes a strong case that there is an underlying mechanism, though: membrane disruption through phospholipidosis.' https://t.co/zf8DBdrfmF
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
This paper shows that Drugs that induced phospholipidosis tend to have have antiviral effects in vitro but not in vivo. #medtwitter https://t.co/raEWnPxRO9
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
@abledoc @AskDrShashank
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not in vivo.
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/PEhOTaNxeu Beautiful research. Worthy to read.
RT @Chemicalprobes2: An off-target effect to be avoided in chemical probes and drugs – phospholipidosis. https://t.co/9MzmVdDgAq
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @abledoc: Why did most drug repurposing efforts fail eventually? Phopholipidosis a side effect of chronic use of cationic amphipathic dr…
RT @abledoc: Why did most drug repurposing efforts fail eventually? Phopholipidosis a side effect of chronic use of cationic amphipathic dr…
Into the valley of Death Rode the six hundred. #InVivoVeritas "To date, over 1,974 drugs and investigational drugs have reported to have in vitro activity against SARS-CoV-2" https://t.co/4asxzVYPov
RT @abledoc: Why did most drug repurposing efforts fail eventually? Phopholipidosis a side effect of chronic use of cationic amphipathic dr…
Covid-19 : Un même biais expliquerait-il les échecs de médicaments repositionnés ? C'est ce que suggère une étude de l'Université de Californie (San Francisco), Novartis et l'Institut Pasteur, publiée mardi dans Science. 👇 https://t.co/j6rMlGnlj1
RT @abledoc: Why did most drug repurposing efforts fail eventually? Phopholipidosis a side effect of chronic use of cationic amphipathic dr…
RT @abledoc: The reason why hopes of drug repurposing from Hydroxychloroquine to Azithromycin and Tamoxifen in treating viral infections cr…
RT @abledoc: The reason why hopes of drug repurposing from Hydroxychloroquine to Azithromycin and Tamoxifen in treating viral infections cr…
The reason why hopes of drug repurposing from Hydroxychloroquine to Azithromycin and Tamoxifen in treating viral infections crash landed. Alll these cationic amphipathic drugs give false positive viral inhibition through a common mechanism: Phospholipidosi
RT @abledoc: Why did most drug repurposing efforts fail eventually? Phopholipidosis a side effect of chronic use of cationic amphipathic dr…
Why did most drug repurposing efforts fail eventually? Phopholipidosis a side effect of chronic use of cationic amphipathic drugs, happen readily in vitro screens giving false flags in screening but is not reproducible in vivo. #DrugRepurposing https://t.
RT @PasteurVirology: Check out the recent findings @ScienceMagazine from an international collaboration on how to improve the search for "…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @PasteurVirology: Check out the recent findings @ScienceMagazine from an international collaboration on how to improve the search for "…
RT @souyakuchan: リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話
RT @souyakuchan: リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話
RT @hswapnil: Derek Lowe @Dereklowe discusses a paper https://t.co/2TzDheQyYr Perhaps HCQ et al in vitro effect was all an artifact anyway…
Derek Lowe @Dereklowe discusses a paper https://t.co/2TzDheQyYr Perhaps HCQ et al in vitro effect was all an artifact anyways? https://t.co/3tJMZl7zD8 https://t.co/t0hFylxRg7
RT @souyakuchan: リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @Chemicalprobes2: An off-target effect to be avoided in chemical probes and drugs – phospholipidosis. https://t.co/9MzmVdDgAq
RT @Chemicalprobes2: An off-target effect to be avoided in chemical probes and drugs – phospholipidosis.
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @Chemicalprobes2: An off-target effect to be avoided in chemical probes and drugs – phospholipidosis.
A confounding effect: cationic amphiphilic drugs (CADs) showed anti-SARS-CoV-2 effects in repurposing screens. But CADs disrupt lipid homeostasis, a toxic effect that does not occur with drug regimens used in vivo, explaining lack of animal efficacy. https
RT @Chemicalprobes2: An off-target effect to be avoided in chemical probes and drugs – phospholipidosis.
An off-target effect to be avoided in chemical probes and drugs – phospholipidosis.
Interesting study, showing that several did proposed for treating covid - including hydroxychloroquine - cause an off target of simply disrupting cell membranes
RT @diegodidibi: Finally this publication in Science addresses a big concern I had for a while...most of the drugs repositioned for against…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/aQlEeoy8Rx https://t.co/X6HUOniPOB
Finally this publication in Science addresses a big concern I had for a while...most of the drugs repositioned for against COVID are do so via a side effect ... https://t.co/ZVt4LTqP3C https://t.co/xrW3lQbIWf
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through phospholipidosis are unlikely to be effective in vivo. Screening out such drugs may allow a focus on drugs with better clinical potential.
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…