RT @marco_heffler: Link paper: https://t.co/CsCVzSvOeq Link riassunto su Science: https://t.co/XBeUM2A4xw 10/11
Link paper: https://t.co/CsCVzSvOeq Link riassunto su Science: https://t.co/XBeUM2A4xw 10/11
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/eKCZIsjqzH #health #covid19
RT @GladstoneInst: 🚨 NEW 🚨 "Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2" @ScienceMagazine @KroganLab https://t…
"There is a strong correlation between drug-induced phospholipidosis and inhibition of SARS-CoV-2 replication in cells. ...(but these drugs) are unlikely to be effective in vivo." Interesting. https://t.co/Q6L4h1XVSl
🚨 NEW 🚨 "Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2" @ScienceMagazine @KroganLab https://t.co/NJRSduRnUC
RT @emulenews: #ScienceMag Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/9ZwToVr6dD There is a stron…
#ScienceMag Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/9ZwToVr6dD There is a strong correlation between drug-induced phospholipidosis and inhibition of SARS-CoV-2 replication in cells. But they are unlikely to be e
a nice lesson from the basic amines..
Why pharmacology is important when a biologist enters to drug discovery field!! Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2: For all of the 23 CADs tested phospholipidosis was monotonically correlated with antiviral efficacy. ht
😷 Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 - Science Magazine 👉 https://t.co/IVrp6Rt4zr 💊 #Medical #GroupZirigoza
ウイルスに効く薬ほど細胞内に蓄積されやすくてウイルスへの効果が期待できないらしい。ワクチン一択か。 Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/p5yra4r0I8
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/2KNOnjixof
New article: Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/w03GoDT2pZ #coronavirus #COVID19 #2019ncov https://t.co/WcrHokBBWl
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/mDYnRaSgRm
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/k7CMfQLjsb
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/TvLW0eJz3Y
RT @BioengIshihara: Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 細胞レベルのスクリーニングでコロナウィルスに効くと思われた薬が、結局のところ動物や人間では効…
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 細胞レベルのスクリーニングでコロナウィルスに効くと思われた薬が、結局のところ動物や人間では効かないことが多いです。その理由を発見した論文です。特効薬を作ることは本当に難しい。 https://t.co/K0zEHhzQdy
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
@bobopopo67 @guy5val @Dalipas Ivermectine sur Hamster par l'Institut Pasteur Et pour enfoncer le clou https://t.co/wxcVrT2f08
@PeterdeWilde10 @eellco @wvlith @WittgensteinsR In petrischaaltjes is dat ook zo. Maar in levende organismen moeten de doses zo hoog zijn dat het link wordt. Of het moet heel langzaam opgebouwd worden, en die tijd heb je niet bij een SARS-CoV-2 infectie. h
COVID-19の治療薬として承認済みの薬から抗SARS-CoV-2活性を示すものをドラッグリポジショニングする試みで多くの化合物が候補に挙がってきたのに、培養細胞実験から臨床試験に移行した段階で上手くいかなかった理由の一つ?がこれなのか。 https://t.co/lCQ2a42Wiw
@Montastrucjl Depuis cette étude, l'explication scientifique est accessible à tous... https://t.co/R3iw7JW9Wi
oops?
2 articles in Science with controversial results Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/fBuv8ix5D7
RT @aledmedwards: Yesterday a covid drug repurposing paper came out in @ScienceMagazine. The week before, also in Science, a “Most hypothe…
Yesterday a covid drug repurposing paper came out in @ScienceMagazine. The week before, also in Science, a “Most hypothesis-free drug repurposing for Covid reports are likely artefacts” paper was published. Amusing. https://t.co/d6JmATeTBG
RT @EganPeltan: Last month @ScienceMagazine published a paper on phospholipidosis interference in drug repurposing Might be a real result,…
Last month @ScienceMagazine published a paper on phospholipidosis interference in drug repurposing Might be a real result, but small effect in small-N mouse study isn’t very convincing https://t.co/VbfQgVekJx
@HartungIngo Published in the same journal too! These papers would have been under review simultaneously. The mastitinib paper has a small-effect, small-N mouse study, but surprisingly no phospholipidosis comment - just an inability to ID escape mutants
@MichelVENTURA12 @Tipuncho @raoult_didier Sources comme celle ci : https://t.co/5JFeztDONd (l'HCQ en fait ca marche meme pas in Vitro)
6/ He says a new paper suggests that Ivermectin works by phospholipidosis – a process akin to hitting a cell with detergent. If this is the mechanism of action, it would kill the cell and essentially be useless as a drug. https://t.co/cmx7VRTGOM
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
@lepeuvemartine @JVerier @ReineCabas Tout est dit dans cette parution récente https://t.co/tMoM1f3rUC
RT @abledoc: Why did most drug repurposing efforts fail eventually? Phopholipidosis a side effect of chronic use of cationic amphipathic dr…
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/ILswBPbrJf
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @CDDVault: Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/wLG9vqaAlq #DrugDiscovery
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/wLG9vqaAlq #DrugDiscovery
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @ConquerCovid_19: Phospholipidosis depends on the physicochemical properties of drugs, and does not reflect specific target-based activi…
Phospholipidosis depends on the physicochemical properties of drugs, and does not reflect specific target-based activities, rather it may be considered a toxic confound in early drug discovery. https://t.co/shEj93ZnH1
RT @momeara: Join us! we're going to discuss our recent paper (Tummino, et al., Science, 2021) https://t.co/ggrrQm8pPz https://t.co/PICHv7Y…
Join us! we're going to discuss our recent paper (Tummino, et al., Science, 2021) https://t.co/ggrrQm8pPz
@PerrinMarc7 @RaymondBouche @ordre_medecins @BouetP @LeGene_hebdo 1 lis l'article. 2 tu trouvera l'étude. https://t.co/OxqbZt3vN8 3 bonne lecture
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/fXQvfMe2pX
クロロキンなどのin vitroでのsars cov 2に対する効果はホスホリピドーシスによるものではないかという論文 Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/fIguj7g8C7
@LobservateurLi1 Pour votre information, voilà pourquoi HCQ et beaucoup d'autres molécules ont des effets in vitro NON reproductibles in vivo. La science progresse, suivez-la! https://t.co/tMoM1f3rUC
RT @AngelaReiersen: This paper demonstrates that drugs which induce phospholipidosis tend to have have antiviral effects in vitro but not i…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
@MARYau_MCU_PH Le gros problème actuellement avec toutes ces molécules découvertes in vitro c'est le biais avec la phospholipidose. Très bien décrit dans ce papier de Pasteur Paris avec @VignuzziLab https://t.co/MJMybogD6y
@cdsouthan This paper surely took out more than a hundred: https://t.co/ztZUCGwm7f https://t.co/xffDlGzqfB
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
The #science is clear that HCT therapy is ineffective in #COVID19 This paper dos a good job of explaining why in vitro testing suggests they might work but in vivo do not Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @AlexSamTG: Je sais plus qui m'a parlé de ce sujet récemment, j'étais sceptique mais j'avais pas vu le papier qui est sorti... Très conv…
Je sais plus qui m'a parlé de ce sujet récemment, j'étais sceptique mais j'avais pas vu le papier qui est sorti... Très convainquant finalement ! https://t.co/ouka2AXtDI ⬇️⬇️⬇️
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
@jcavailles @OlivierLebon5 @djocal @GuillaumeRozier @olivierveran C'est un article de science. Vous ne vous seriez pas ridiculisé si vous aviez lu l'article... https://t.co/PQdH8GhiC9
Hydroxychloroquine and re-purposed cationic amphiphilic drugs (CADs) appear to disrupt fundamental cellular function. They don't have a future as anti-viral, specifically anti-COVID drugs. https://t.co/6D3v5LRAYV https://t.co/X0bwa5eDiu
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @silex_transl: #HCQ 等23種の #転用COVID19 薬の「抗ウイルス効果」が、#CADs によるリソソームリン脂質擾乱効果に還元されることを示す。ビトロ実験で顕著、resources will be saved by counter-screenin…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
@Drmartyufml @MartineWonner @BouetP @ordre_medecins @MartineWonner Vous qui demandiez l'an passé pourquoi in vitro l'HCQ avait des résultats, voilà la réponse. Bonne lecture! https://t.co/tMoM1f3rUC
On pari combien que le druide marseillais va nous sortir, avec le plus grand aplomb du monde, un truc du genre « Science? C’est une revue de minables, la preuve j’y ai jamais rien publié »? @Sonic_urticant @Curiolog
Wow. This has so been missing from the SARS-CoV-2 drug repurposing scene. Insightful chemistry & medicinal chemistry breaks down that many of these repurposed agents just induce phospholipidosis and are likely a waste of ⏳ and 💵 in the clinic. https://
RT @souyakuchan: リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話 https://t.co/ysX1K6WaeU
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
@julienpotet Une piste d'explication des biais des tests de repositionnement "in vitro" https://t.co/hP5L0crexj
https://t.co/h3xlnZlct8 @BpsmithUk
@AssoCovid @autrement_votre @DIVIZIO1 https://t.co/Frh4RSznIq et donc ces quelques chercheurs sont supérieurs au prof Raoult et à ce prix Nobel qui défend l'ivermectine? C'est vite dit !
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @silex_transl: #HCQ 等23種の #転用COVID19 薬の「抗ウイルス効果」が、#CADs によるリソソームリン脂質擾乱効果に還元されることを示す。ビトロ実験で顕著、resources will be saved by counter-screenin…
RT @silex_transl: #HCQ 等23種の #転用COVID19 薬の「抗ウイルス効果」が、#CADs によるリソソームリン脂質擾乱効果に還元されることを示す。ビトロ実験で顕著、resources will be saved by counter-screenin…
RT @silex_transl: #HCQ 等23種の #転用COVID19 薬の「抗ウイルス効果」が、#CADs によるリソソームリン脂質擾乱効果に還元されることを示す。ビトロ実験で顕著、resources will be saved by counter-screenin…
RT @silex_transl: #HCQ 等23種の #転用COVID19 薬の「抗ウイルス効果」が、#CADs によるリソソームリン脂質擾乱効果に還元されることを示す。ビトロ実験で顕著、resources will be saved by counter-screenin…
RT @silex_transl: #HCQ 等23種の #転用COVID19 薬の「抗ウイルス効果」が、#CADs によるリソソームリン脂質擾乱効果に還元されることを示す。ビトロ実験で顕著、resources will be saved by counter-screenin…
RT @silex_transl: #HCQ 等23種の #転用COVID19 薬の「抗ウイルス効果」が、#CADs によるリソソームリン脂質擾乱効果に還元されることを示す。ビトロ実験で顕著、resources will be saved by counter-screenin…
RT @silex_transl: #HCQ 等23種の #転用COVID19 薬の「抗ウイルス効果」が、#CADs によるリソソームリン脂質擾乱効果に還元されることを示す。ビトロ実験で顕著、resources will be saved by counter-screenin…
RT @roby_bhatt: Part of what I love about this paper is: the authors are poking holes in their own prior drug-repurposing work (https://t.c…
What chances of a filter score for these? AI based even?
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/J10uesqtSx
RT @roby_bhatt: Fascinating paper (https://t.co/cZc6detzwW) & commentary (https://t.co/XncZUPp7Pk) on a common mechanism of confounding for…