RT @StrangVirusLab: Important info on why no in vivo activity vs SARS-CoV-2 “all of the 23 cationic amphiphilic drugs tested, including h…
RT @pmarsupia: ¿Por qué no ha funcionado ningún antiviral frente al coronavirus? Este artículo es interesantísimo. No me cansaré de repeti…
RT @PasteurVirology: Check out the recent findings @ScienceMagazine from an international collaboration on how to improve the search for "…
RT @pmarsupia: ¿Por qué no ha funcionado ningún antiviral frente al coronavirus? Este artículo es interesantísimo. No me cansaré de repeti…
RT @pmarsupia: ¿Por qué no ha funcionado ningún antiviral frente al coronavirus? Este artículo es interesantísimo. No me cansaré de repeti…
¿Por qué no ha funcionado ningún antiviral frente al coronavirus? Este artículo es interesantísimo. No me cansaré de repetirlo: la biología es mil veces más complicada que la teoría cuántica de cuerdas.
RT @StrangVirusLab: Important info on why no in vivo activity vs SARS-CoV-2 “all of the 23 cationic amphiphilic drugs tested, including h…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
Why Hydroxychloroquine was thought to work. It created an effect (phospholipidosis) that worked (antiviral) in cell-based assays, but not in humans. https://t.co/5LyGGZZGUo
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @MilkaKostic: Many hits identified in drug repurposing screens for SARS-CoV-2 seem to induce phospholipidosis, and that this poorly unde…
RT @edward_marcotte: Ouch. "Many drugs repurposed... against SARS-CoV-2 ... likely [act] via a single shared mechanism: phospholipidosis."…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
Many hits identified in drug repurposing screens for SARS-CoV-2 seem to induce phospholipidosis, and that this poorly understood process, not specific target engagement is behind their antiviral activity as well as dose limiting toxicity. 🤔 https://t.co/I
Really interesting and useful paper I’m not surprised to see the compounds we identified with a basic VeroE6 screen more than one year ago https://t.co/fLmwHCapea
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
Check out the recent findings @ScienceMagazine from an international collaboration on how to improve the search for "drugs with genuine promise as antivirals" With participation of our own @VignuzziLab and @Virus_Immunity members @BlandineMonel @tvallet1
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @StrangVirusLab: Important info on why no in vivo activity vs SARS-CoV-2 “all of the 23 cationic amphiphilic drugs tested, including h…
El reposicionament d'antivirals contra el SARS-COV-2 continua sense reeixir.
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in Science: Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/432YXtqsmK
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @StrangVirusLab: Important info on why no in vivo activity vs SARS-CoV-2 “all of the 23 cationic amphiphilic drugs tested, including h…
RT @fraser_lab: Paper of the year! Seriously... read this! So much $ and time wasted through an artifactual signal in drug repurposing.
Important artifact in covid drug repurposing!! 👇
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
Pour tous ceux qui portent attention aux travaux de repositionnement de certaines molécules pour trouver un traitement contre la #COVID19. #Chemistry #drugs
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
Top #science story: Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 | Science https://t.co/640qxnJLne, see more https://t.co/zYmGuZ3rN9
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/PeHcAFtl11
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @edward_marcotte: Ouch. "Many drugs repurposed... against SARS-CoV-2 ... likely [act] via a single shared mechanism: phospholipidosis."…
Ouch. "Many drugs repurposed... against SARS-CoV-2 ... likely [act] via a single shared mechanism: phospholipidosis." Because of side effects and limited efficacy, these drugs are "unlikely to translate in vivo." Relevant to >100 clinical trials. http
Cationic amphiphilic drugs (CADs) can provoke phospholipidosis characterized by formation of vesicle-like structures thought to arise by disruption of lipid homeostasis. Modulation of lipid processing pathways critical for viral replication.
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
Very important read on SARS-CoV-2 drug repurposing https://t.co/4EP8EnK7RX
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/a443sNuaE3
RT @fraser_lab: Paper of the year! Seriously... read this! So much $ and time wasted through an artifactual signal in drug repurposing.
RT @thelonevirologi: Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/KivnEcN4t9
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
@BShoichet I’m wondering if this hasn’t been an open secret in pharma for some time?!
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @cispt2: Disappointed @BShoichet - I predicted Nature https://t.co/7VNPZQus1e
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @cispt2: Disappointed @BShoichet - I predicted Nature https://t.co/7VNPZQus1e
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
Disappointed @BShoichet - I predicted Nature
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @JPottel: Congratulations on this massive, fantastic work Tia Tummino, @BShoichet lab, and collaborators. Very cool stuff!
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @fraser_lab: Paper of the year! Seriously... read this! So much $ and time wasted through an artifactual signal in drug repurposing.
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @fraser_lab: Paper of the year! Seriously... read this! So much $ and time wasted through an artifactual signal in drug repurposing.
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 https://t.co/KivnEcN4t9
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)