RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
Before we all get too excited about popping LNP's, remember these are cationic amphiphillic complexes of mRNA vaccines. Clearance rates and dosing frequency are relevant - but remember many CADs are safe https://t.co/h4yB7PPml9
@DrLCsquare For those involved with N-nitrosamine risk assessments, Fig 1 will have you running for the hills. 😱 https://t.co/jBQwFh9Fj2
RT @Samuel_Bakhoum: 🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈Drug-induced phospholipidosis confounds drug repurposing @ScienceMagazine https://t.co/3w4RpKeQS8
RT @fraser_lab: Paper of the year! Seriously... read this! So much $ and time wasted through an artifactual signal in drug repurposing.
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @souyakuchan: リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @fraser_lab: Paper of the year! Seriously... read this! So much $ and time wasted through an artifactual signal in drug repurposing. htt…
RT @fraser_lab: Paper of the year! Seriously... read this! So much $ and time wasted through an artifactual signal in drug repurposing. htt…
RT @fraser_lab: Paper of the year! Seriously... read this! So much $ and time wasted through an artifactual signal in drug repurposing. htt…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @PasteurVirology: Check out the recent findings @ScienceMagazine from an international collaboration on how to improve the search for "…
RT @fraser_lab: Paper of the year! Seriously... read this! So much $ and time wasted through an artifactual signal in drug repurposing.
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @fraser_lab: Paper of the year! Seriously... read this! So much $ and time wasted through an artifactual signal in drug repurposing.
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @SababaUSA: We now likely know why so many drugs appearing to have promising anti-COVID activity in a test tube, like hydroxychloroquine…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @souyakuchan: リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @Samuel_Bakhoum: 🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈Drug-induced phospholipidosis confounds drug repurposing @ScienceMagazine https://t.co/3w4RpKeQS8
RT @PasteurVirology: Check out the recent findings @ScienceMagazine from an international collaboration on how to improve the search for "…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈🙈Drug-induced phospholipidosis confounds drug repurposing @ScienceMagazine https://t.co/3w4RpKeQS8
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
RT @DARPA: Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such…
Researchers working on DARPA's PANACEA program have identified a mechanism that may help explain why many repurposed drugs (such as hydroxychloroquine) that appeared to be active antivirals against SARS-CoV-2 were not ultimately effective when tested in hu
What's maddening is that the knowledge has been there for some time https://t.co/uCbmcxnpqc https://t.co/OHQyydUnQP We just had a lot of new people doing repurposing during COVID and some lost their marbles when it came to doing the proper validations.
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @MilkaKostic: Many hits identified in drug repurposing screens for SARS-CoV-2 seem to induce phospholipidosis, and that this poorly unde…
😷 Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 - Science 👉 https://t.co/vQ9q7zAZBE 💊 #Medical #GroupZirigoza
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @NovartisScience: Many repurposed drugs that looked like they might combat #COVID19 when tested in cell lines proved unsuccessful in cli…
RT @MilkaKostic: Many hits identified in drug repurposing screens for SARS-CoV-2 seem to induce phospholipidosis, and that this poorly unde…
RT @souyakuchan: リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話 https://t.co/ysX1K6WaeU
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @souyakuchan: リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話
RT @souyakuchan: リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話
RT @NovartisScience: Many repurposed drugs that looked like they might combat #COVID19 when tested in cell lines proved unsuccessful in cli…
RT @souyakuchan: リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話
Fascinating paper here from @Novartis , @UCSF and @institutpasteur looking at drug repurposing and the confouding factors in finding suitable drugs against Sars-CoV-2. https://t.co/sJCoUkVoD8
RT @souyakuchan: リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話
リポジショニングでコロナに効きそうとされ(て結局だめだっ)た薬の多くは大体カチオン性両親媒性薬でホスホリピドーシスの惹起によって見かけ上効いていたのではという話
Many repurposed drugs that looked like they might combat #COVID19 when tested in cell lines proved unsuccessful in clinical trials. What happened? Scientists may have found a possible explanation. https://t.co/NW2CfJx6TR https://t.co/R0IUkdVkbX
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @StrangVirusLab: Important info on why no in vivo activity vs SARS-CoV-2 “all of the 23 cationic amphiphilic drugs tested, including h…
RT @BShoichet: This paper now out in Science https://t.co/4TQBSx6Mml. Key observations: (1/N)
Seems to me that experts could have, and should have, been asking themselves “do these in vitro hits have something in common seemingly unrelated to their pharmaco/bioactivity?” We absolutely could have noticed all the apparent hits including HCQ were cati
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @fraser_lab: Paper of the year! Seriously... read this! So much $ and time wasted through an artifactual signal in drug repurposing.
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
We now likely know why so many drugs appearing to have promising anti-COVID activity in a test tube, like hydroxychloroquine and azithromycin, have consistently failed in clinical trials. A great shame nobody noticed this far sooner https://t.co/KoguwfG6o
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @pmarsupia: ¿Por qué no ha funcionado ningún antiviral frente al coronavirus? Este artículo es interesantísimo. No me cansaré de repeti…
RT @VignuzziLab: Our collaboration with @BShoichet lab @QBI_UCSF and @NovartisScience on our/the troubles with drug repurposing now out in…
RT @pmarsupia: ¿Por qué no ha funcionado ningún antiviral frente al coronavirus? Este artículo es interesantísimo. No me cansaré de repeti…
RT @pmarsupia: ¿Por qué no ha funcionado ningún antiviral frente al coronavirus? Este artículo es interesantísimo. No me cansaré de repeti…
RT @pmarsupia: ¿Por qué no ha funcionado ningún antiviral frente al coronavirus? Este artículo es interesantísimo. No me cansaré de repeti…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @pmarsupia: ¿Por qué no ha funcionado ningún antiviral frente al coronavirus? Este artículo es interesantísimo. No me cansaré de repeti…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @pmarsupia: ¿Por qué no ha funcionado ningún antiviral frente al coronavirus? Este artículo es interesantísimo. No me cansaré de repeti…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…
RT @zenbrainest: Must read for all pharmacologists, chemical biologists and drug-hunters! A pesky artifact finally revealed!! https://t.co…
RT @ScienceMagazine: As repurposing drugs for #COVID19 has drawn much attention, a new study shows that drugs w/ antiviral effect through p…